| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 化学名 | P-methyl-P-(1,2,3,6-tetrahydro-4-pyridinyl)-phosphinic acid, hydrate |
| Canonical SMILES | CP(C1=CCNCC1)(O)=O.O |
| 分子式 | C6H12NO2P.XH2O |
| 分子量 | 161.1 |
| 溶解度 | PBS (pH 7.2): 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TPMPA is a GABAA-Ρ1 (Ρ1 GABAC) receptor antagonist that is 8-fold selective for GABAA-Ρ1 over GABAA-Ρ2 (Ρ2 GABAC) receptors expressed inX. laevisoocytes (Kbs = 2 and 16 μM, respectively).1In rat hippocampal slices, TPMPA blocks the inhibitory effect of the GABABagonist 3-APMPA on excitatory postsynaptic currents (EPSCs) with an EC50value of 490 μM.2TPMPA (100 μM) increases light sensitivity and the maximal response of rat retinal ganglion cells without altering their dynamic range.3In sleeping rats, TPMPA (50 μg, i.c.v.) increases waking from 45 to 62% compared to a vehicle control and decreases slow-wave and paradoxical sleep (REM) by 11 and 5.4%, respectively.4 1.Chebib, M., Mewett, K.N., and Johnston, G.A.GABAC receptor antagonists differentiate between human Ρ1 and Ρ2 receptors expressed in Xenopus oocytesEur. J. Pharmacol.357(2-3)227-234(1998) 2.Ragozzino, D., Woodward, R.M., Murata, Y., et al.Design and in vitro pharmacology of a selective γ-aminobutyric acidC receptor antagonistMol. Pharmacol.50(4)1024-1030(1996) 3.Jensen, R.J.Blocking GABAC receptors increases light responsiveness of retinal ganglion cells in a rat model of retinitis pigmentosaExp. Eye Res.10521-26(2012) 4.Arnaud, C., Gauthier, P., and Gottesmann, C.Study of a GABAC receptor antagonist on sleep-waking behavior in ratsPsychopharmacology (Berl)154(4)415-419(2001) |
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