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TFB-TBOA(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TFB-TBOA(hydrate)图片
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An inhibitor of EAAT1 and EAAT2
Canonical SMILESFC(F)(F)C1=CC=C(C(NC2=CC=CC(CO[C@H](C(O)=O)[C@H](N)C(O)=O)=C2)=O)C=C1.O
分子式C19H17F3N2O6.XH2O
分子量426.3
溶解度DMSO: 30 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TFB-TBOA is an inhibitor of excitatory amino acid transporter 1 (EAAT1) and EAAT2 with IC50values of 22 and 17 nM for EAAT1 and EAAT2, respectively, in a glutamate uptake assay using COS-1 cells.1It is selective for EAAT1 and EAAT2 over EAAT3 (IC50= 300 nM), as well as the choline, dopamine, GABA, norepinephrine, and serotonin transporters and a variety of neurotransmitter receptors at 10 µM. TFB-TBOA (10 µM) inhibits L-glutamate- and L-aspartate-induced currents inX. laevisoocytes. It induces convulsions in mice when administered at a dose of 0.2 µg/animal.

1.Shimamoto, K., Sakai, R., Takaoka, K., et al.Characterization of novel L-threo-β-benzyloxyaspartate derivatives, potent blockers of the glutamate transportersMol. Pharmacol.65(4)1008-1015(2004)