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PYD-106
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PYD-106图片
CAS NO:1560894-05-4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
PYD-106 是一种立体选择性吡咯烷酮 (PYD) 正向变构调节剂,用于含有 GluN2C 的 NMDA 受体。
Cas No.1560894-05-4
Canonical SMILESCC1=C(CCN2C(C3=CC=C(C(OC)=O)C=C3)C(C(C)=O)=C(O)C2=O)C4=CC=CC=C4N1
分子式C25H24N2O5
分子量432.5
溶解度DMSO: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PYD-106 is a positive allosteric modulator of NR2C subunit-containing NMDA receptors (NMDARs).1It enhances glutamate-induced maximal current responses in HEK293 cells expressing NR1/NR2C NMDA receptors (EC50= 13 µM). PYD-106 is selective for NR2C subunit-containing NMDA receptors over NRA-, NR2B-, and NR2D-subunit containing NMDA receptors inXenopusoocytes expressing NR1/NR2 heteromeric NMDA receptors at 30 µM.

1.Khatri, A., Burger, P.B., Swanger, S.A., et al.Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulatorMol. Pharmacol.86(5)548-560(2014)