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FK-506-13C-d2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
FK-506-13C-d2图片
CAS NO:1356841-89-8
包装:1mg
市场价:12081元

产品介绍
An internal standard for the quantification of FK-506
Cas No.1356841-89-8
别名他克莫司-13C,FK506-13C,d2; Fujimycin-13C,d2; FR900506-13C,d2
Canonical SMILESO=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]3C/C=[13C]([2H])\[2H])=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)[C@H](C)[C@@H](O)CC3=O
分子式C43[13C]H67D2NO12
分子量807
溶解度Chloroform: Slightly Soluble,Methanol: Slightly Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

FK-506-13C-d2contains two deuterium atoms located on the carbon-13 bond. It is intended for use as an internal standard for the quantification of FK-506 by GC- or LC-MS. FK-506 is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin.1Its mechanism of action involves the formation of a high affinity complex (Ki= 0.2 nM) with FK-506 Binding Protein 12 (FKBP12). This complex then inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T cell activation.2The physiological effects of FK-506 also include regulation of nitric oxide neurotoxicity, neurotransmitter release, and regulation of Ca2+releaseviathe ryanodine and inositol-(1,4,5)-trisphosphate (IP3) receptors.3In the latter case, FKBP12 forms a tight complex with both ryanodine and IP3receptors which can be disrupted by FK-506, thereby rendering the receptors "leaky" to Ca2+.

1.Schreiber, S.L.Chemistry and biology of the immunophilins and their immunosuppressive ligandsScience251(4991)283-287(1991) 2.Dumont, F.J.FK506, An immunosuppressant targeting calcineurin functionCurr. Med. Chem.7(7)731-748(2000) 3.Snyder, S.H., Sabatini, D.M., Lai, M.M., et al.Neural actions of immunophilin ligandsTrends Pharmacol. Sci.19(1)21-26(1998)