| CAS NO: | 16502-01-5 |
| 包装 | 价格(元) |
| 1 g | 电议 |
| 5 g | 电议 |
| Cas No. | 16502-01-5 |
| 别名 | 1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚 |
| Canonical SMILES | C1(C=CC=C2)=C2C(CCNC3)=C3N1 |
| 分子式 | C11H12N2 |
| 分子量 | 172.2 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.33 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 1,2,3,4-Tetrahydro-β-carboline is a serotonin reuptake inhibitor (IC50= 7.4 µM in rat brain homogenates) and metabolite of tryptamine .1In vivo, 1,2,3,4-tetrahydro-β-carboline (20 and 40 µg/animal, i.c.v.) reduces serotonin levels in rat forebrain. It induces serotonin-mediated hyperactivity syndrome (HHS) in rats (ED50= 48 mg/kg).21,2,3,4-Tetrahydro-β-carboline (6.25-75 mg/kg) also reduces acetic acid-induced writhing in rats.3 1.Rommelspacher, H., Bade, P., Coper, H., et al.Inhibition of the reuptake of serotonin by tryptolineNaunyn Schmiedebergs Arch. Pharmacol.292(1)93-95(1976) 2.Pannier, L., and Rommelspacher, H.Actions of tetrahydronorharmane (tetrahydro-β-carboline) on 5-hydroxytryptamine and dopamine mediated mechanismsNeuropharmacology20(1)1-8(1981) 3.Rommelspacher, H., Kauffmann, H., Cohnitz, C.H., et al.Pharmacological properties of tetrahydronorharmane (tryptoline)Naunyn Schmiedebergs Arch. Pharmacol.298(2)83-91(1977) |
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