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Vonoprazan Fumarate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Vonoprazan Fumarate图片
CAS NO:881681-01-2
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
VonoprazanFumarate(TAK-438)是有一种口服活性的钾竞争性酸阻断剂，抑制H+,K+-ATPase的IC50值为19nM。
Cas No.881681-01-2
别名富马酸沃诺拉赞; TAK-438
Canonical SMILESO=C(O)/C=C/C(O)=O.O=S(N1C=C(CNC)C=C1C2=CC=CC=C2F)(C3=CC=CN=C3)=O.[(E)]
分子式C21H20FN3O6S
分子量461.46
溶解度DMSO: 50 mg/mL (108.35 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Vonoprazan Fumarate (TAK-438) is an orally active potassium-competitive acid blocker which inhibits H+, K+-ATPase activity with an IC50 of 19 nM.

[1]. Arikawa Y, et al. Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem, 2012, 55(9), 4446-4456. [2]. Hori Y, et al. 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther, 2010, 335(1), 231-238. [3]. Hori Y, et al. A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. J Pharmacol Exp Ther, 2011, 337(3), 797-804.