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Minoxidil sulfate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Minoxidil sulfate图片
CAS NO:83701-22-8
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Minoxidilsulfate是一种有效的ATP敏感的K+通道(K+channel)激动剂,是米诺地尔的硫酸代谢物。Minoxidilsulfate被认为是一种血管扩张试剂,在动物实验模型中,促进头发生长。
Cas No.83701-22-8
别名米诺地尔硫酸盐
Canonical SMILESNC1=NC(N2CCCCC2)=CC(N1OS(=O)(O)=O)=N
分子式C9H15N5O4S
分子量289.31
储存条件Store at -20℃, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Minoxidil sulfate, a potent and ATP-sensitive K+ channel opener, is the sulfated metabolite of minoxidil. Minoxidil sulfate is considered as a vasodilator to promote hair growth in vivo[1][3].

Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration[2].Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS[2]. Western Blot Analysis[2] Cell Line: Rat brain microvascular endothelial cells (RBMECs)

[1]. A E Buhl, et al. Minoxidil sulfate is the active metabolite that stimulates hair follicles. J Invest Dermatol. 1990 Nov;95(5):553-7. [2]. Yan-ting Gu, et al. Minoxidil sulfate induced the increase in blood-brain tumor barrier permeability through ROS/RhoA/PI3K/PKB signaling pathway.Neuropharmacology 2013 Dec;75:407-15.doi: 10.1016/j.neuropharm. [3]. Y Nakaya, et al.Effect of minoxidil sulfate and pinacidil on single potassium channel current in cultured human outer root sheath cells and dermal papilla cells. J Dermatol Sci. 1994 Jul;7 Suppl:S104-8.