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5&alpha-Pregnane-3&beta,6&alpha-diol-20-one
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5&alpha-Pregnane-3&beta,6&alpha-diol-20-one图片
CAS NO:21853-11-2
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议

产品介绍
5α-Pregnane-3β,6α-diol-20-one是一种促进有丝分裂的progesterone代谢物,可于血清不足时雄性激素反应的前列腺素癌细胞中产生。
Cas No.21853-11-2
Canonical SMILESC[C@@]12[C@]3([H])[C@](C[C@H](O)[C@@]1([H])C[C@@H](O)CC2)([H])[C@@]4([H])[C@@](C)([C@@H](C(C)=O)CC4)CC3
分子式C21H34O3
分子量334.49
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.

Progesterone is converted to 5α-pregnane-3β,6α-diol-20-one in human fibroblasts[1]. Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β,6α-diol-20-one in the C4.2 cell line, with nearly complete conversions at 24 h and 18 h, respectively. Preferential 5α-pregnan-3β,6α-diol-20-one formation from early steroid precursors is independent of CYP17A1 but rather relies on 3β-HSD activity[2].

[1]. Zhang J, et al. Progesterone metabolism in human fibroblasts is independent of P-glycoprotein levels and Niemann-Pick type C disease. J Steroid Biochem Mol Biol. 1999 Sep-Oct;70(4-6):123-31. [2]. de Mello Martins AGG, et al. CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone. J Steroid Biochem Mol Biol. 2017 Nov;174:183-191.