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Clofibric Acid-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Clofibric Acid-d4图片
CAS NO:1184991-14-7
包装与价格:
包装价格(元)
500 µg电议
1mg电议
5mg电议
10mg电议

产品介绍
An internal standard for the quantification of clofibric acid
Cas No.1184991-14-7
别名Chlorofibrinic acid-d4
Canonical SMILESOC(C(C)(C)OC1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)=O
分子式C10H7ClD4O3
分子量218.7
溶解度Acetonitrile: soluble,DMSO: soluble,Methanol: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Clofibric acid-d4is intended for use as an internal standard for the quantification of clofibric acid by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50= 50 µM in a transactivation assay) and the active metabolite of clofibrate .1It is formed from clofibrate by tissue and serum esterases.2Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats.3It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (C. carpio) when administered in tank water at a concentration of 10 µg/L.4Clofibric acid has been found in wastewater effluent.5

1.Giampietro, L., Laghezza, A., Cerchia, C., et al.Novel phenyldiazenyl fibrate analogues as PPAR α/γ/δ pan-agonists for the amelioration of metabolic syndromeACS Med. Chem. Lett.10(4)545-551(2019) 2.Cayen, M.N.Metabolic disposition of clofibrateDrug Metabol. Drug Interact.3(1 & 2)77-103(1980) 3.Cayen, M.N., Ferdinandi, E.S., Greselin, E., et al.Clofibrate and clofibric acid: Comparison of the metabolic disposition in rats and dogsJ. Pharmacol. Exp. Ther.200(1)33-43(1977) 4.Saravanan, M., Karthika, S., Malarvizhi, A., et al.Ecotoxicological impacts of clofibric acid and diclofenac in common carp (Cyprinus carpio) fingerlings: Hematological, biochemical, ionoregulatory and enzymological responsesJ. Hazard. Mater.195188-194(2011) 5.Tixier, C., Singer, H.P., Oellers, S., et al.Occurrence and fate of carbamazepine, clofibric acid, diclofenac, ibuprofen, ketoprofen, and naproxen in surface watersEnviron. Sci. Technol.37(6)1061-1068(2003)