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Debrisoquin(hemisulfate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Debrisoquin(hemisulfate)图片
CAS NO:581-88-4
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议
250mg电议

产品介绍
A post-ganglionic sympathetic blocker
Cas No.581-88-4
别名硫酸异喹胍
Canonical SMILESNC(N1CCC2=CC=CC=C2C1)=N.O=S(O)(O)=O
分子式C10H13N3• 1/2H2SO4
分子量224.3
溶解度PBS (pH 7.2): 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Debrisoquin is a post-ganglionic sympathetic blocker.1 It increases accumulation of the monoamine oxidase (MAO) substrate l-m-octopamine in isolated rabbit heart when used at a concentration of 1 mM.2 Debrisoquin reduces norepinephrine levels in the left and right atrium and ventricles, as well as the mesenteric and femoral arteries in anesthetized dogs when administered at a dose of 5 mg/kg per day for seven days.3 Debrisoquin decreases mean aortic pressure, heart rate, and total peripheral vascular resistance in the same model.

|1. Heffernan, A.G.A., and Carty, A.T. Clinical observations on the use of debrisoquine sulphate (declinax) in the treatment of hypertension. I. J. Med. Sc. 3(1), 37-43 (1970).|2. Giachetti, A., and Shore, P.A. Monoamine oxidase inhibition in the adrenergic neuron by bretylium, debrisoquin, and other adrenergic neuronal blocking agents. Biochem. Pharmacol. 16, 237-238 (1966).|3. Cavero, I., Gerold, M., Saner, A., et al. The cardiovascular effects of the antihypertensive drug debrisoquin: A contribution to the pharmacology of chronic treatment. I. one-week administration to dogs. J. Pharmacol. Exp. Ther. 206(1), 123-131 (1978).