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DVD-445
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DVD-445图片
CAS NO:2375846-41-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
DVD-445 (Compound 7) 是一种有效的拟肽共价硫氧还蛋白还原酶1 (TrxR1) 抑制剂,IC50 为 0.60 μM。DVD-445 具有良好的抗癌应用。
Cas No.2375846-41-4
分子式C25H28F2N2O4
分子量458.5
溶解度DMSO : 100 mg/mL (218.10 mM; ultrasonic and warming and heat to 60°C)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 0.60 μM (rat TrxR1)[1]

DVD-445 (Compound 7) is a potent peptidomimetic covalentthioredoxin reductase 1 (TrxR1)inhibitor with anIC50of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application[1].

DVD-445 (Compound 7) shows a cytotoxic effect in SH-SY5Y, U87, HaCaT cell lines and PBMCs withIC50s of 10.99 μM, 9.70 μM, 8.30 μM, 55.71 μM, respectively[1].