| CAS NO: | 693241-54-2 |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| Cas No. | 693241-54-2 |
| 别名 | 2-(4-(2-甲氧基苯甲酰氨基)苯甲酰氨基)苯甲酸 |
| 分子式 | C22H18N2O5 |
| 分子量 | 390.39 |
| 溶解度 | DMSO : 83.33 mg/mL (213.45 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | EG1, a specific Pax2 inhibitor, directly binds the paired domain of Pax2 (Kd=1.35-1.5 μM) and inhibits Pax2-DNA interactions. EG1 can inhibit embryonic kidney development, a process directly dependent on Pax2 activity[1]. EG1 (0-12.5 μM; 48 hours) decreases viability in Pax2 positive renal cancer cell lines[1].EG1 (0-500 μM) is capable of inhibiting Pax2 mediated expression of EGFP without significant effects on Pax2 protein levels[1]. [1]. Grimley E, et al. Inhibition of Pax2 Transcription Activation with a Small Molecule that Targets the DNA Binding Domain. ACS Chem Biol. 2017;12(3):724-734. |
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