| CAS NO: | 314245-65-3 |
| 包装: | 1mg |
| 市场价: | 9450元 |
| Cas No. | 314245-65-3 |
| Canonical SMILES | O=C(NC(C1)=O)CC1CCCC([C@H]([C@]2([H])/C(C)=C\[C@H]([C@@H]([C@H](/C=C/CC/C=C/C(O2)=O)OC)O)C)C)=O |
| 分子式 | C27H39NO7 |
| 分子量 | 489.6 |
| 溶解度 | DMF: soluble,DMSO: soluble,Methanol: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Migrastatin is a bacterial metabolite that has been found inStreptomyceswith antimuscarinic and anticancer activities.1,2It binds to M1-5muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 µM, respectively) and inhibits calcium mobilization induced by carbamoylcholine in SK-N-SH cells (IC50= 28 µM), as well as in primary rat bladder smooth muscle cells.1Migrastatin inhibits the migration of EC17 esophageal cancer cells in a wound healing assay (IC50= 10 µg/ml) and 4T1 mouse mammary carcinoma cells in a chamber cell migration assay (IC50= 29 µM).2It enhances cytotoxicity induced by vinblastine in vincristine-resistant P388/VCR cells.3 1.Nakae, K., Nishimura, Y., Ohba, S., et al.Migrastatin acts as a muscarinic acetylcholine receptor antagonistJ. Antibiot. (Tokyo)59(11)685-692(2006) 2.Reymond, S., and Cossy, J.Migrastatin and analogues: New anti-metastatic agentsC. R. Chim.11(11-12)1447-1462(2008) 3.Takemoto, Y., Tashiro, E., and Imoto, M.Suppression of multidrug resistance by migrastatinJ. Antibiot. (Tokyo)59(7)435-438(2006) |
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