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ADL 08-0011(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ADL 08-0011(hydrochloride)图片
CAS NO:170098-43-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An active metabolite of alvimopan
Cas No.170098-43-8
别名阿维莫潘代谢物(ADL08-0011)盐酸盐
Canonical SMILESC[C@]1(C2=CC(O)=CC=C2)[C@H](CN(CC1)C[C@@H](C(O)=O)CC3=CC=CC=C3)C.Cl
分子式C23H29NO3·HCl
分子量403.9
溶解度DMSO: soluble,Methanol: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan .1It is produced from alvimopanviaamide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki= 0.25 nM). It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2= 9.4).In vivo, ADL 08-0011 (0.03-1 mg/kg) reverses loperamide-induced delayed gastric emptying in a rat model of castor oil-induced diarrhea.2

1.Beattie, D.T., Cheruvu, M., Mai, N., et al.The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexoneNaunyn Schmiedebergs Arch. Pharmacol.375(3)205-220(2007) 2.Armstrong, S.R., Campbell, C.B., Richardson, C.L., et al.The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activityNaunyn Schmiedebergs Arch Pharmacol.386(6)471-478(2013)