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10-hydroxy Warfarin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
10-hydroxy Warfarin图片
CAS NO:83219-99-2
包装与价格：
包装价格(元)
500 µg电议
1mg电议

产品介绍
A metabolite of (R)-warfarin
Cas No.83219-99-2
别名10-羟基华法林(非对映体的混合物)
Canonical SMILESOC(C1=CC=CC=C1O2)=C(C(C3=CC=CC=C3)C(O)C(C)=O)C2=O
分子式C19H16O5
分子量324.3
溶解度DMSO: slightly soluble,Methanol: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

10-hydroxy Warfarin is a metabolite of (R)-warfarin .1It is formed from (R)-warfarin by the cytochrome P450 (CYP) isoform CYP3A4. 10-hydroxy Warfarin is an inhibitor of CYP2C9 (IC50= 1.6 µM), the enzyme that converts (S)-warfarin to its 6-hydroxy warfarin and 7-hydroxy warfarin metabolites.2

1.Kaminsky, L.S., and Zhang, Z.-Y.Human P450 metabolism of warfarinPharmacol. Ther.73(1)67-74(1997) 2.Jones, D.R., Kim, S.-Y., Guderyon, M., et al.Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarinChem. Res. Toxicol.23(5)939-945(2010)