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ALK-IN-5
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ALK-IN-5图片
CAS NO:2351929-66-1
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
ALK-IN-5 是一种高效选择性的，可渗透大脑屏障的 (ALK) 激酶抑制剂，IC50 值为 2.9 nM。
Cas No.2351929-66-1
Canonical SMILESO=C(C1=CN(C2=NNC(C)=C2)C3=NC(O[C@H](C4=NC=C(F)C=C4)C)=CC=C31)N5C[C@H](C)OCC5
分子式C24H25FN6O3
分子量464.49
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK), with an IC50 of 2.9 nM[1]. IC50: 2.9 nM (ALK)[1]

ALK-IN-5 potently inhibits ALK with cellular IC50 of 27 nM[1].

[1]. Fushimi M, et al. Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors. J Med Chem. 2019 May 23;62(10):4915-4935.