| CAS NO: | 56563-17-8 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 56563-17-8 |
| Canonical SMILES | O=C(N(C(N1)=O)C=C(F)C1=O)NC2=CC=CC=C2 |
| 分子式 | C11H8FN3O3 |
| 分子量 | 249.2 |
| 溶解度 | DMSO: 5 mg/mL (20.06 mM) |
| 储存条件 | 4°C, protect from light, stored under nitrogen |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1]. PluriSIn #2 (20 µM; 12 hours) treatment reduces TOP2A expression at the protein level[1].A 24h exposure of PluriSIn #2 (20 µM) is sufficient to induce massive cell death in hPSCs, but doesn't affect the viability of various other cell types derived from them[1]. Western Blot Analysis[1] Cell Line: B153 and HUES9 human pluripotent stem cells (hPSCs) [1]. Uri Ben-David, et al. Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha. Stem Cells. 2015 Mar;33(3):1013-9. |
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