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LDN-91946
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
LDN-91946图片
CAS NO:439946-22-2
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
50mg电议

产品介绍
LDN-91946是一种有效的非竞争性的选择性泛素羧基末端水解酶-L1(UCH-L1)抑制剂，Kiapp为2.8μM.
Cas No.439946-22-2
Canonical SMILESOC(C1=CC2=C(SC(C(C3=CC=CC=C3)=O)=C2N)NC1=O)=O
分子式C15H10N2O4S
分子量314.32
溶解度DMSO: 83.33 mg/mL (265.11 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM[1].

LDN-91946 is inactive against UCH-L3 at 20 μM. LDN-91946 demonstrates no activity against TGase 2, Papain, and Caspase-3 at 40 μM[1]. There is no cytotoxicity when serum-starved Neuro 2A (N2A) cells are treated with LDN-91946 at concentrations as high as 0.1 mM[1].

[1]. Mermerian AH, et al. Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3729-32.