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DHODH-IN-11
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DHODH-IN-11图片
CAS NO:1263303-95-2
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
DHODH-IN-11(Compound14b)是一种Leflunomide衍生物，也是一种二氢乳清酸脱氢酶(DHODH)的弱抑制剂，其pKa为5.03。
Cas No.1263303-95-2
Canonical SMILESO=C(NC1=CC=C(C2=CC=CC=C2)C=C1)/C(C#N)=N/O
分子式C15H11N3O2
分子量265.27
溶解度DMSO: 125 mg/mL (471.22 mM)
储存条件-20°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03[1].

Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 14a), is designed. Compound 14a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-11 (Compound 14b). DHODH-IN-14 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure[1].

[1]. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92.