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CH-0793076 TFA
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CH-0793076 TFA图片
包装:1mg
市场价:7650元

产品介绍
CH-0793076(TP3076)TFA，喜树碱的六环类似物，是TP300的活性药物和主要代谢物。CH-0793076TFA抑制DNA拓扑异构酶I(DNAtopoisomeraseI)，IC50为2.3μM。CH-0793076TFA对表达BCRP(乳腺癌耐药蛋白)的细胞也有活性。
别名TP3076 TFA
Canonical SMILESO=C1[C@](O)(CC)C(C=C23)=C(CO1)C(N2CC(C3=N4)=C5N(CCCCC)C=NC6=C5C4=CC=C6)=O.O=C(O)C(F)(F)F
分子式C28H27F3N4O6
分子量572.53
溶解度DMSO: 66.67 mg/mL (116.45 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CH-0793076 (TP3076) TFA, a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 TFA inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 TFA is efficacious against cells expressing BCRP (breast cancer resistance protein)[1].

CH0793076 (TP3076) TFA (6 days at 37°C) shows antiproliferative activity against PC-6/BCRP and PC-6/pRC cells, with IC50s of 0.35 and 0.18 nM, respectively[1].

[1]. Endo M, et al. A water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts. Cancer Chemother Pharmacol. 2010 Jan;65(2):363-71.