AZT triphosphate TEA

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装:	1mg
市场价:	5850元

产品介绍

AZTtriphosphateTFA(3'-Azido-3'-deoxythymidine-5'-triphosphateTFA)是一种Zidovudine(AZT)的活性三磷酸酯代谢产物。AZTtriphosphateTFA具有抗逆转录病毒的活性，并抑制HIV复制。AZTtriphosphateTFA还可抑制HBV的DNA聚合酶。AZTtriphosphateTFA可激活线粒体介导的凋亡(apoptosis)途径。

别名	3'-Azido-3'-deoxythymidine-5'-triphosphate TEA
Canonical SMILES	O=C(NC(C(C)=C1)=O)N1[C@H](O2)C[C@H](N=[N+]=[N-])[C@H]2COP(O)(OP(OP(O)(O)=O)(O)=O)=O.CCN(CC)CC.[x]
分子式	C₁₀H₁₆N₅O₁₃P₃.xC₆H₁₅N
储存条件	Store at -20℃
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3]. Treatment with 100 µM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts[1]. [1]. Ryosuke Nomura, et al. Azidothymidine-triphosphate Impairs Mitochondrial Dynamics by Disrupting the Quality Control System. Redox Biol. 2017 Oct;13:407-417. [2]. Takeya Sato, et al. Engineered Human tmpk/AZT as a Novel Enzyme/Prodrug Axis for Suicide Gene Therapy. Mol Ther. 2007 May;15(5):962-70. [3]. K Y Hostetler, et al. Enhanced Oral Absorption and Antiviral Activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and Related Compounds in Hepatitis B Virus Infection, in Vitro. Biochem Pharmacol. 1997 Jun 15;53(12):1815-22.