| CAS NO: | 67763-87-5 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
Bleomycinhydrochloride是一种DNA损伤剂，抑制DNA合成。Bleomycinhydrochloride是一种抗肿瘤抗生素(antibiotic)。
| Cas No. | 67763-87-5 |
| 别名 | 盐酸博来霉素 |
| Canonical SMILES | NC(C[C@H](NC[C@@H](N)C(N)=O)C1=NC(N)=C(C)C(C(N[C@H](C(N[C@@H](C)[C@@H]([C@@H](C)C(N[C@@H](C(NCCC2=NC(C3=NC(C(NCCC[S+](C)C)=O)=CS3)=CS2)=O)[C@H](O)C)=O)O)=O)C(C4=CNC=N4)O[C@@H]5[C@]([H])(O[C@@H]6[C@@H](O)[C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](O)[C@@H](CO)O5)=O)=N1)=O.[Cl-] |
| 分子式 | C55H84ClN17O21S3 |
| 分子量 | 1451 |
| 溶解度 | DMSO: 125 mg/mL (86.15 mM) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 文献引用 | |
| 产品描述 | Bleomycin hydrochloride is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin hydrochloride is an antitumor antibiotic[1]. Bleomycin is chosen as the best-studied micronucleus inducers in human lymphocytes with different mechanisms of genotoxicity. The most frequent Bleomycin-induced DNA lesions are single and double strand breaks and single apuinic/apyrimidinic sites. At the same time Bleomycin is true radiomimetic compound, resembling almost completely the genetic effect of ionizing radiation[1]. The IC50 value of Bleomycin for UT-SCC-19A cell line is 4.0±1.3 nM. UT-SCC-12A and UT-SCC-12B are both more resistant to Bleomycin; IC50 values are 14.2±2.8 nM and 13.0±1.1 nM, respectively[2]. Bleomycin treatment (3.5-4.0 mg/kg; intra-tracheal) on day 0, body weights decreases by day 4 then increases by Day 7 through the end of the study[3].Bleomycin (3.5-4.0 mg/kg; intra-tracheal) produces a statistically significant increase in lung hydroxyproline levels, and also increases right caudal lung lobe mass[3]. Animal Model: Male Fischer 344 rats, 8-10 week old, weighing 150-250 g[3] References: |
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