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EIDD-1931
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
EIDD-1931图片
CAS NO:3258-02-4
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) 是一种新型核苷类似物，可作为有效的抗病毒剂。
Cas No.3258-02-4
别名N-羟基胞苷, β-D-N4-Hydroxycytidine, N4-Hydroxycytidine
化学名uridine, 4-oxime
Canonical SMILESO[C@@H]1[C@@H](CO)O[C@](N2C(N=C(NO)C=C2)=O)([H])[C@@H]1O
分子式C9H13N3O6
分子量259.2
溶解度20mg/mL in DMSO, 10mg/mL in DMF
储存条件Store at -20°C,unstable in solution, ready to use.
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

EIDD-1931 is a ribonucleoside analog with antiviral activity.[1],[2],[3],[4] It inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV) in Vero 76 cells, Middle East respiratory syndrome coronavirus (MERS-CoV) in Calu-3 2B4 cells, and SARS-CoV-2 in Vero cells (IC50s =0.1, 0.15 and 0.3 μM, respectively).[3],[4] It also reduces viral titers of Venezuelan equine encephalitis virus (VEEV) TC-83 in infected Vero cells (EC50 = 0.426 μM) and wild-type and remdesivir-resistant strains of the model CoV mouse hepatitis virus (MHV) in infected DBT cells.[2][4] EIDD-1931 (100 and 400 mg/kg twice per day) reduces lung viral titers in mouse models of respiratory syncytial virus (RSV) and H1N1 influenza A virus infection.[1]

Reference:
[1]. Yoon, J.-J., Toots, M., Lee, S., et al. Orally efficacious broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses. Antimicrob. Agents Chemother. 62(8), e00766-00718 (2018).
[2]. Urakova, N., Kuznetsova, V., Crossman, D.K., et al. β-D-N4-Hydroxycytidine Is a potent anti-alphavirus compound that induces a high level of mutations in the viral genome. J. Virol. 92(3), e01965-01917 (2018).
[3]. Barnard, D.L., Day, C.W., Bailey, K., et al. Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice. Antivir. Chem. Chemother. 17(5), 275-784 (2006).
[4]. Sheahan, T.P., Sims, A.C., Zhou, S., et al. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Sci. Transl. Med. 12:eabb5883, (2020).