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6RK73
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
6RK73图片
CAS NO:1895050-66-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
6RK73 是一种共价不可逆的特异性 UCHL1 抑制剂,IC50 为 0.23 µM。6RK73 对 UCHL3 几乎没有抑制效果 (IC50=236 µM)。6RK73 特异性抑制乳腺癌中 UCHL1 的活性。
Cas No.1895050-66-4
Canonical SMILESO=C([C@@H]1CN(C#N)CC1)NC2=NC=C(N3CCOCC3)S2
分子式C13H17N5O2S
分子量307.37
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC50=236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer[1].

[1]. Liu S, et al. Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis. Clin Cancer Res. 2019 Dec 19. pii: clincanres.1373.2019.