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SQ609
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
SQ609图片
CAS NO:627052-25-9
包装与价格：
包装价格(元)
25mg电议
50mg电议

产品介绍
SQ609 是一种来自二哌啶库的先导化合物。SQ609 在 4μg/ml时抑制 90% 以上的细胞内细菌生长，并且对这些细胞有毒。SQ609 显示出强大的抗结核活性。
Cas No.627052-25-9
分子式C22H38N2O
分子量346.55
溶解度DMSO : 6.67 mg/mL (19.25 mM; ultrasonic and warming and heat to 60°C)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SQ609 is a lead compound from a library of dipiperidines. SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells. SQ609 displays a potent antitubercular activity [1].

In Mtb-infected macrophages in vitro, SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells[1].

SQ609 (10 mg/kg; intravenous injection) completely prevents weight loss in the Mtb-infected animals and prolongs the therapeutic effect following drug withdrawal for another 10-15 days[1].

[1]. Bogatcheva E, et al. Identification of SQ609 as a lead compound from a library of dipiperidines. Bioorg Med Chem Lett. 2011;21(18):5353-5357.