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Tosyl Phenylalanyl Chloromethyl Ketone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tosyl Phenylalanyl Chloromethyl Ketone图片
CAS NO:402-71-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
Tosyl Phenylalanyl Chloromethyl Ketone (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-Tosyl Phenylalanyl Chloromethyl Ketone) 是一种有效的丝氨酸蛋白酶抑制剂,可与 HPV-18 E7 蛋白的视网膜母细胞瘤蛋白 (RB) 结合核心反应并消除它的RB结合能力。
Cas No.402-71-1
别名L-1,4'-甲基磺酰基-2-苯基乙基氯甲基酮,L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK
Canonical SMILESCC1=CC=C(S(N[C@H](C(CCl)=O)CC2=CC=CC=C2)(=O)=O)C=C1
分子式C17H18ClNO3S
分子量351.8
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tosyl phenylalanyl chloromethyl ketone (TPCK) is an irreversible inhibitor of chymotrypsin-like proteases that has been shown to affect cell proliferation, apoptosis, and tumorigenesis. It can disrupt PDK1 signaling to the AGC kinases, Akt, S6K1, and RSK, as well as MSK1 and MSK2. TPCK also inhibits superoxide production and suppresses neutrophil respiratory burst.