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QX77
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
QX77图片
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
QX77是分子伴侣介导的自噬(CMA)激活剂。

Cell experiment:

Mouse embryo fibroblasts are preincubated with QX77 or vehicle (DMSO) 48 h before the addition of tert-butyl hydroperoxide. After an overnight incubation, cell viability is determined by a modified version of the MTT assay[1].

产品描述

QX77 is a chaperone-mediated autophagy (CMA) activator.

Treatment with CMA activator QX77 rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells. QX77 treatment also increases LAMP2A localization at the lysosomal membrane[1].

[1]. Zhang J, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017 Jun 23;292(25):10328-10346.