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LY2955303
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
LY2955303图片
CAS NO:1433497-19-8
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
LY2955303 是一种有效的选择性视黄酸受体 γ (RARγ) 拮抗剂，Ki 为 1.09 nM。
Cas No.1433497-19-8
Canonical SMILESCC(C)(C1=CC(C(C)(C)C)=CC(C2=CC(C3=CC=C(C(O)=O)C=C3)=NN2C4=CC=C(C(N5CCN(C)CC5)=O)C=C4)=C1)C
分子式C36H42N4O3
分子量578.74
溶解度DMSO : 30 mg/mL (51.84 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LY2955303 is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM.

LY2955303 is tested and observed that the binding Kis for RARα, RARβ and RARγ are >1700, >2980 and 1.09 nM, respectively. The functional Ki for RARγ is 7.1±4.9 nM[1].

A single oral dose of LY2955303 demonstrates a dose responsive effect whereby the rat reduces differential weight bearing (ED50=0.72 mg/kg)[1].

References:
[1]. Hughes NE, et al. Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3274-3277.