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Fosinopril-d7(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fosinopril-d7(sodium salt)图片
CAS NO:1217819-83-4
包装:1mg
市场价:5519元

产品介绍
An internal standard for the quantification of fosinopril
Cas No.1217819-83-4
Canonical SMILES[O-]C([C@@H]1C[C@@](CN1C(C[P@](O[C@@H](C(C)C)OC(CC)=O)(CCCC([2H])([2H])C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O)=O)([H])C3CCCCC3)=O.[Na+]
分子式C30H38D7NO7P.Na
分子量592.7
溶解度Acetonitrile:Methanol (1:1): Soluble,DMSO: Soluble,Water: Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Fosinopril-d7is intended for use as an internal standard for the quantification of fosinopril by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme (ACE) inhibitor fosinoprilat.1Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril (2.5 mg/kg) reduces fractional shortening and decreases left ventricular size in a porcine model of congestive heart failure.2Formulations containing fosinopril have been used in the treatment of hypertension and congestive heart failure.

1.DeForrest, J.M., Waldron, T.L., Harvey, C., et al.Fosinopril, a phosphinic acid inhibitor of angiotensin I converting enzyme: In vitro and preclinical in vivo pharmacologyJ. Cardiovasc. Pharmacol.14(5)730-736(1989) 2.McElmurray, J.H., III, Mukherjee, R., New, R.B., et al.Angiotensin-converting enzyme and matrix metalloproteinase inhibition with developing heart failure: Comparative effects on left ventricular function and geometryJ. Pharmacol. Exp. Ther.291(2)799-811(1999)