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VU0238441
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
VU0238441图片
CAS NO:85511-68-8
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
VU0238441是泛毒蕈碱型乙酰胆碱受体(mAChR)阳性变构调节剂(PAM)，对M1，M2，M3，M5和M4的EC50分别为3.2μM，2.8μM，2.2μM，2.1μM和>10μM。
Cas No.85511-68-8
Canonical SMILESO=C1N(CC2=CC=C(C(F)(F)F)C=C2)C3=C(C=CC=C3Cl)C1=O
分子式C16H9ClF3NO2
分子量339.7
溶解度DMSO: 125 mg/mL (367.97 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively[1][2].

VU0238441 is an analogue of VU0119498[2].

[1]. Thomas M Bridges, et al. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM. Bioorg Med Chem Lett. 2010 Jan 15;20(2):558-62. [2]. Thomas M Bridges, et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem. 2009 Jun 11;52(11):3445-8.