| CAS NO: | 55-43-6 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 250mg | 电议 |
| Cas No. | 55-43-6 |
| 别名 | N-(2-氯乙基)二苄胺盐酸盐,N-?(2-?Chloroethyl)?dibenzylamine hydrochloride |
| Canonical SMILES | ClCCN(CC1=CC=CC=C1)CC2=CC=CC=C2.[H]Cl |
| 分子式 | C16H19Cl2N |
| 分子量 | 296.23 |
| 溶解度 | DMSO: 125 mg/mL (421.97 mM) |
| 储存条件 | 4℃, away from moisture |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Dibenamine hydrochloride is a competitive and irreversible adrenergic blocking agent and is known to modify the pharmacological effects of epinephrine. Dibenamine hydrochloride cause a significant increase in the rate of destruction of I-epinephrine in the mouse[1][2]. Dibenamine (100 nM-10 μM) attenuates the degree of cocaine-induced increase in sensitivity to acetylcholine without any effect on acetylcholine-contraction in isolated vas deferens of guinea pig. Additionally, the degree of dibenamine-induced inhibition dependent on the concentration of dibenamine and inversely related to the concentration of cocaine[3]. Dibenamine hydrochloride (subcutaneous injection; 25 mg/kg; 48 and 24 hr before the administration of CCl4) decreases the CHCl3, levels at 2 and 6 hr by 30-50 percent, but did not appreciably affect the half-life of CHCl3, in the liver.Pretreatment with Dibenamine apparently slows the conversion of Ccl4 to CHCL3[1]. [1]. R W SCHAYER, et al. Effect of dibenamine (N-(2-chloroethyl) dibenzylamine) on the metabolism of radioactive epinephrine.J Biol Chem. 1953 May;202(1):39-43. [2]. H M Maling,et al. Nature of the protection against carbon tetrachloride-induced hepatotoxicity produced by pretreatment with dibenamine (N-(2-chloroethyl)dibenzylamine). Biochem Pharmacol. 1974 May 15;23(10):1479-91. [3]. K Araki, et al. Pharmacological studies on supersensitization. VII. Inhibitory effect of dibenamine on cocaine-induced supersensitivity of isolated vas deferens of guinea pig. J Pharmacobiodyn. 1982 Oct;5(10):789-95. |
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