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D3-βArr
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
D3-βArr图片
CAS NO:662164-09-2
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议

产品介绍
D3-βArr是一种促甲状腺激素受体正变构调节剂,通过促甲状腺激素受体直接激活启动β-Arr1的易位,并增强促甲状腺激素介导的体外成骨细胞分化。
Cas No.662164-09-2
别名2-甲氧基-4-(4-甲基哌嗪-1-基)苯胺
Canonical SMILESCC(NC1=C2C=CC=CC2=NC(N3CCNCC3)=N1)C4=CC=CC=C4
分子式C20H23N5
分子量333.43
溶解度DMSO: ≥ 125 mg/mL (374.89 mM)
储存条件4℃, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro[1].

[1]. Neumann S, et al. Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45.