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Prostaglandin A1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Prostaglandin A1图片
CAS NO:14152-28-4
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍

Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen.

Cas No.14152-28-4
别名前列腺素A1,PGA1
化学名9-oxo-15S-hydroxy-prosta-10,13E-dien-1-oic acid
Canonical SMILESCCCCCC(O)/C=C/[C@H]1C=CC(=O)C1CCCCCCC(=O)O
分子式C20H32O4
分子量336.5
溶解度50mg/mL in ethanol, or in DMSO, or in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen.[1] It has been shown to cause renal vasodilation, increased urine sodium excretion, and lowered arterial pressure in hypertensive patients.[2] It also has growth-inhibitory activity on tumor cells; the IC50 value for the inhibition of human ovarian cancer is 7.5 μM.[3]

Reference:
[1]. Hamberg, M., and Samuelsson, B. Prostaglandins in human seminal plasma. The Journal of Biological Chemisty 241, 257-263 (1966).
[2]. Krakoff, L.R., Vlachakis, N., Mendlowitz, M., et al. Differential effect of prostaglandin A1 in hypertensive patients with low, normal and high renin. Clinical Science and Molecular Medicine 48, 311s-313s (1975).
[3]. Kikuchi, Y., Kita, T., Hirata, J., et al. Preclinical studies of antitumor prostaglandins by using human ovarian cancer cells. Cancer Metastasis Rev. 13(3-4), 309-315 (1994).