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Antisauvagine-30(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
包装与价格：
包装价格(元)
500 µg电议
1mg电议

产品介绍
A peptide CRF2antagonist
Canonical SMILESO=C([C@@H](CC1=CC=CC=C1)N)N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@]([H])([C@H](CC)C)C(N[C@H](C(N[C@@]([H])([C@H](CC)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@]([H])(C(N[C@@]([H])([C@H](CC)C)C(N)=O)=O)[C@@H](C)O)=O)CC(O)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CC(N)=O)=O)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCCCN[H])=O)CCC(O)=O)=O)CCCCN[H])=O)CCC(O)=O)=O)CCC(N)=O)=O)CCCCN[H])=O)CCC(O)=O)=O)=O)CCC(O)=O)=O)=O)CCSC)=O)CCCCN[H])=O)CCCNC(N)=N)=O)=O)=O)CC2=CNC=N2.OC(C(F)(F)F)=O
分子式C161H274N48O46S·XCF3COOH
分子量3650.3
溶解度Water: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Antisauvagine-30 is a peptide antagonist of corticotropin-releasing factor receptor 2 (CRF2).1,2It is selective for CRF2αover CRF1(Kis = 1.75 and 915 nM, respectively for the human receptors).1Antisauvagine-30 (10 nM) inhibits sauvagine-induced cAMP production in HEK293 cells expressing mouse CRF2β.2It prevents stress-induced contextual fear conditioning in mice.3Antisauvagine-30 reduces vasoactive intestinal peptide-induced decreases in food intake in rats.4

1.Dautzenberg, F.M., Py-Lang, G., Higelin, J., et al.Different binding modes of amphibian and human corticotropin-releasing factor type 1 and type 2 receptors: Evidence for evolutionary differencesJ. Pharmacol. Exp. Ther.296(1)113-120(2001) 2.RÜhmann, A., Bonk, I., Lin, C.R., et al.Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): Development of CRFR2β-selective antisauvagine-30Proc. Natl. Acad. Sci. USA95(26)15264-15269(1998) 3.Sananbenesi, F., Fischer, A., Schrick, C., et al.Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: A possible link between stress and fear memoryJ. Neurosci.23(36)11436-11443(2003) 4.Garnica-Siqueira, M.C., Martins, A.B., Zaia, D.A.M., et al.Corticotrophin-releasing factor mediates vasoactive intestinal peptide-induced hypophagia and changes in plasma parametersHorm. Behav.105138-145(2018)