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PF 9601N
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF 9601N图片
CAS NO:133845-63-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
An inhibitor of MAO-B
Cas No.133845-63-3
Canonical SMILESC#CCNCC1=CC2=C(N1)C=CC(OCC3=CC=CC=C3)=C2
分子式C19H18N2O
分子量290.4
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 20 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PF 9601N is an inhibitor of monoamine oxidase B (MAO-B).1It selectively inhibits MAO-B in mouse brain homogenatesex vivo(ID50= 381 nmol/kg) and prevents MPTP-induced reductions in dopamine levels in the striatum of 8- to 9-week-old mice when administered at doses ranging from 29.5 to 8.47 µmol/kg. PF 9601N (0.027 µmol/kg) prevents MPTP-induced lesions in 9- to 10-month-old mice. It also increases the duration of contralateral rotational behavior induced by L-DOPA in a rat model of Parkinson’s disease induced by 6-OHDA when administered at doses of 40 and 60 mg/kg.2

1.Perez, V., and Unzeta, M.PF 9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine], a new MAO-B inhibitor, attenuates MPTP-induced depletion of striatal dopamine levels in C57/BL6 miceNeurochem. Int.42(3)221-229(2003) 2.Prat, G., PÉrez, V., Rubi, A., et al.The novel type B MAO inhibitor PF9601N enhances the duration of L-DOPA-induced contralateral turning in 6-hydroxydopamine lesioned ratsJ. Neural Transm. (Vienna)107(4)409-417(2000)