Piracetam-d₆is intended for use as an internal standard for the quantification of piracetam by GC- or LC-MS. Piracetam is a nootropic cyclic GABA derivative.¹It is a positive allosteric modulator of AMPA receptors and enhances binding of the NMDA antagonist MK-801 to rat forebrain membranes.^2,3Piracetam (1 mM) protects against amyloid-β-induced decreases in the mitochondrial membrane potential, as well as decreases in neurite outgrowth in the presence of NGF, in PC12 rat adrenal medulla cells.⁴It prevents scopolamine-induced amnesia in a passive avoidance test in mice when administered at a dose of 30 mg/kg.⁵Formulations containing piracetam have been used in the treatment of myoclonus.

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