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5-Hydroxylansoprazole
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
5-Hydroxylansoprazole图片
CAS NO:131926-98-2
包装:1mg
市场价:1260元

产品介绍
5-Hydroxylansoprazole(AG1908)是血浆中Lansoprazole的活性代谢产物。Lansoprazole由CYP2C19代谢形成5-Hydroxylansoprazole。Lansoprazole是一种胃质子泵(proton-pump)抑制剂，可有效研究各种消化系统疾病。
Cas No.131926-98-2
别名5-羟基兰索拉唑,AG1908
Canonical SMILESOC1=CC=C2N=C(NC2=C1)S(CC3=NC=CC(OCC(F)(F)F)=C3C)=O
分子式C16H14F3N3O3S
分子量385.36
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole in plasma. Lansoprazole is metabolized by CYP2C19 forming 5-Hydroxylansoprazole. Lansoprazole is a gastric proton-pump inhibitor and is effective in the treatment of various peptic diseases[1][2].

[1]. Xu HR, et al. The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects. Pharm Biol. 2010 Aug;48(8):947-52. doi: 10.3109/13880200903300220. [2]. KatarÍna KostolanskÁ, et al. Determination of lansoprazole, 5-hydroxylansoprazole, and lansoprazole sulfone in human plasma for CYP2C19 and CYP3A4 phenotyping. Chemical Papers. volume 73, pages2955-2963(2019).