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Ropivacaine mesylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ropivacaine mesylate图片
CAS NO:854056-07-8
包装与价格:
包装价格(元)
10mM (in 1mL Water)电议
10mg电议
50mg电议

产品介绍
Ropivacaine mesylate 是一种氨基酰胺化合物,有阻断神经性疼痛的作用。Ropivacaine mesylate 是一种 K2P (双孔钾通道) TREK-1 抑制剂,在 COS-7 细胞膜上其 IC50 值为 402.7 μM。Ropivacaine mesylate 能在急性高血压模型中抑制压力诱导的肺内皮细胞高通透性。
Cas No.854056-07-8
别名甲磺酸罗哌卡因
Canonical SMILESO=C([C@H]1N(CCC)CCCC1)NC2=C(C)C=CC=C2C.CS(=O)(O)=O
分子式C18H30N2O4S
分子量370.51
溶解度Water: 250 mg/mL (674.75 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ropivacaine mesylate is an aminoamide compound, effectively blocks neuropathic pain. Ropivacaine mesylate is an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine mesylate inhibits pressure-induces lung endothelial hyperpermeability in models of acute hypertension[1][2].

[1]. Li TF, et al. Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain. PLoS One. 2015 Jan 24;10(1):e0117321. [2]. Milan Patel, et al. Ropivacaine Inhibits Pressure-Induced Lung Endothelial Hyperpermeability in Models of Acute Hypertension. Life Sci. 2019 Apr 1;222:22-28.