CAS NO: | 930800-38-7 |
包装: | 5mg |
市场价: | 855元 |
Cas No. | 930800-38-7 |
别名 | N-己-5-炔基-2-碘乙酰胺,Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide |
Canonical SMILES | ICC(=O)NCCCCC#C |
分子式 | C8H12INO |
分子量 | 265.09 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Broad spectrum cysteine reactive probe. Covalently binds cysteine residues in proteins. Can be utilized for covalent fragment-based ligand discovery (FBLD) and to identify Zn2+-binding cysteines. Used as a click-chemistry handle to attach a fluorophore or biotin to reactive cysteines in proteins for visualization by in-gel fluorescence or identification by mass spectrometry, respectively. Covalently binds cysteine residues in and activates TRPA1 channels. Backus et al (2016) Proteome-wide covalent ligand discovery in native biological systems. Nature 534 570 PMID:27309814 |Pace and Weerapana et al (2014) A competitive chemical-proteomic platform to identify zinc-binding cysteines. ACS Chem.Biol. 9 258 PMID:24111988 |Macpherson et al (2007) Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445 541 PMID:17237762 |