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OptoBI-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
OptoBI-1图片
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
OptoBI-1 是一种光致变色 TRPC3 激动剂,可作为一种光药理学工具来控制神经元放电。
Canonical SMILESCCCCC1=CC=C(/N=N/C2=CC=C(C=C2)CCCC(N3CCC(N4C(NC5=CC=CC=C45)=O)CC3)=O)C=C1
分子式C32H37N5O2
分子量523.67
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Photoswitchable TRPC3/6/7 agonist (EC50 for active cis-form ~0.1 μM at TRPC3). Switches conformation from trans to cis at 365 nm and cis to trans at 430 nm. Returns to trans conformation in the dark after ~ 50 minutes. No effect observed on TRPC4 or 5. Rapidly changes TRPC3 conductance and inhibits neuronal firing in cis-state.

Tiapko et al (2019) Lipid-independent control of endothelial and neuronal TRPC3 channels by light. Chem.Sci. 10 2837 |Curcic et al (2019) Photopharmacology and opto-chemogenetics of TRPC channels-some therapeutic visions. Pharmacol.Ther. 200 13 PMID:30974125 |Curcic et al (2019) TRPC-mediated Ca2+ signaling and control of cellular functions. Semin.Cell Dev.Biol. 94 28 PMID:30738858 |Lichtenegger et al (2018) An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel. Nat.Chem.Biol. 14 396 PMID:29556099