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BTD
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BTD图片
CAS NO:896684-04-1
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Cas No.896684-04-1
Canonical SMILESCC1=CC=C2C(NC(CCC(=O)NCCCOC34CC5CC(CC(C5)C3)C4)=N[S]2(=O)=O)=C1
分子式C24H33N3O4S
分子量459.61
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Selective TRPC5 activator (EC50 = 1.4 μM in a calcium influx assay, 1.3 μM in whole cell patch clamp assay). Displays >14.5-fold selectivity for TRPC5 over other TRP channels (EC50 = 20.6 μM for TRPM8). Also activates TRPC1:5 and TRPC4:5 heteromers.

Beckmann et al (2017) A benzothiadiazine derivative and methylprednisolone are novel and selective activators of transient receptor potential canonical 5 (TRPC5) channels. Cell Calcium. 66 10 PMID:28807145