| CAS NO: | 667427-75-0 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 667427-75-0 |
| Canonical SMILES | COC1=C(OC)C=C2C(CC(C)(C)N=C2C2=CC3=CC=CC=C3OC2=O)=C1 |
| 分子式 | C22H21NO4 |
| 分子量 | 363.41 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Selective TRPC6 positive allosteric modulator. Selectively activates TRPC6 over other TRP channels. Also activates TRPA1. Induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 (EC50 = 2.37 μM). Potentiates OAG (1-oleoyl-1-acetyl-sn-glycerol)-induced Ca2+ influx in human platelets, and enhances OAG-induced platelet aggregation. Häfner et al (2019) Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels. Cell Calcium 78 26 PMID:30594060 |
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