您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > ASP 7663
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
ASP 7663
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ASP 7663图片
CAS NO:1190217-35-6
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
ASP 7663 是一种具有口服活性和选择性的 TRPA1 激动剂。
Cas No.1190217-35-6
Canonical SMILESO=C2/C(C1=CC=CC(F)=C1N2CC(C)C)=C/C(O)=O
分子式C14H14FNO3
分子量263.26
溶解度DMSO: 25 mg/ml,Ethanol: 25 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat). Displays little or no affinity at more than 60 other related receptors, channels and enzymes. Stimulates 5-HT release from QGP-1 cells. Exhibits an abdominal analgesic effect in vivo. Orally bioavailable.

Kojima et al (2014) Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. Eur.J.Pharmacol. 723 288 PMID:24291101