您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > Amino-PEG10-OH
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Amino-PEG10-OH
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Amino-PEG10-OH图片
CAS NO:129449-09-8
包装:1g
市场价:5199元

产品介绍
Amino-PEG10-OH 是一种不可降解 (non-cleavable) 的 10 单元 PEG-ADC 连接物，用于抗体偶联药物 (ADC) 的合成。Amino-PEG10-OH 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。
Cas No.129449-09-8
分子式C20H43NO10
分子量457.56
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Amino-PEG10-OH is non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG10-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. James Bailey, et al. Non peptidic heterobivalent molecules for treating inflammatory diseases. WO2018134731A1.