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Amino-PEG11-OH
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Amino-PEG11-OH图片
CAS NO:15332-94-2
包装:1g
市场价:6092元

产品介绍
Amino-PEG11-OH 是一种不可降解 (non-cleavable) 的 11 单元 PEG 类 ADC 连接物，用于抗体偶联药物 (ADC) 的合成。Amino-PEG11-OH 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。
Cas No.15332-94-2
分子式C22H47NO11
分子量501.61
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Amino-PEG11-OH is non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG11-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Synthesis of reduced sensitive azo connection unit and application of azo connection unit in DNA (deoxyribonucleic acid) sequencing. CN103539697A.