DBCO-NHCO-PEG4-amine

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	1255942-08-5
包装:	1g
市场价:	15638元

产品介绍

DBCO-NHCO-PEG4-amine 是一种 PROTAC 连接桥，属于 PEG 类。DBCO-NHCO-PEG4-amine 是一种可降解 (cleavable) 的 ADC linker，可用于连接 MMAE 和抗体 (例如 DBCO-VCpAB-MMAE 和 DBCO-TRX-MMAE，对 SKBR3 细胞的 EC50 分别为 280 nM 和 22 nM)。

Cas No.	1255942-08-5
分子式	C₂₉H₃₇N₃O₆
分子量	523.62
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	DBCO-NHCO-PEG4-amine is a PEG-basedPROTAC linkercan be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavableADC linkerused to conjugate MMAE and antibody (e.g., DBCO-VCpAB-MMAE and DBCO-TRX-MMAE with EC₅₀s of 280 nM and 22 nM in SKBR3 cells, respectively)^[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. [1]. Spangler B, et al. Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. Mol Pharm. 2018 May 7;15(5):2054-2059. .