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m-PEG7-CH2CH2CHO
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
m-PEG7-CH2CH2CHO图片
CAS NO:1234369-95-9
包装:1g
市场价:8714元

产品介绍
m-PEG7-CH2CH2CHO 是一种不可降解 (non-cleavable) 的 ADC linker，用于抗体偶联药物 (ADC) 的合成。m-PEG7-CH2CH2CHO 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。
Cas No.1234369-95-9
分子式C18H36O9
分子量396.47
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

m-PEG7-CH2CH2CHO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG7-CH2CH2CHO is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Erwin R. Boghaert, et al. Anti-egfr antibody drug conjugates. WO2017214282A1.