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FAPI-46
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FAPI-46图片
CAS NO:2374782-04-2
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
FAPI-46 是一种基于喹啉的靶向成纤维细胞活化蛋白 (FAP) 的放射性示踪剂。FAPI-46 具有更高的肿瘤吸收率和增长的肿瘤积累时间。FAPI-46 可用于多种不同癌症的肿瘤成像。
Cas No.2374782-04-2
分子式C41H57F2N11O9
分子量885.96
溶解度DMSO : 100 mg/mL (112.87 mM; Need ultrasonic)
储存条件4°C, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted radiotracer. FAPI-46 has higher tumor uptake and prolonged tumor accumulation. FAPI-46 can be used for tumor imaging of a multitude of different cancers[1][2].

FAPI-46 (1-24 h) robustly binds to human FAP in human FAP-expressing HT-1080 cells[1].

FAPI-46 (i.v.) shows improved ratios of tumor to liver, kidney, and brain uptake, resulting in an enhanced image contrast for PET imaging[1].

[1]. Loktev A, et, al. Development of Fibroblast Activation Protein-Targeted Radiotracers with Improved Tumor Retention. J Nucl Med. 2019 Oct;60(10):1421-1429.
[2]. Moon ES, et, al. Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA 5m chelators. EJNMMI Radiopharm Chem. 2020 Jul 29;5(1):19.