CAS NO: | 1092484-56-4 |
包装 | 价格(元) |
500 μg | 电议 |
1mg | 电议 |
5mg | 电议 |
Cas No. | 1092484-56-4 |
别名 | 非诺贝特 d6 |
Canonical SMILES | ClC1=CC=C(C(C2=CC=C(OC(C([2H])([2H])[2H])(C(OC(C)C)=O)C([2H])([2H])[2H])C=C2)=O)C=C1 |
分子式 | C20H15ClD6O4 |
分子量 | 366.9 |
溶解度 | DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: 1 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Fenofibrate-d6is intended for use as an internal standard for the quantification of fenofibrate by GC- or LC-MS. Fenofibrate is an agonist of peroxisome proliferator-activated receptor α (PPARα) with EC50values of 18 and 30 μM for mouse and human receptors, respectively, in a transactivation assay.1It is selective for PPARα over PPARγ (EC50s = 300 and 200 μM for mouse and human receptors, respectively) and lacks activity at mouse and human PPARδ at a concentration of 100 μM.In vivo, fenofibrate (50-100 mg/kg) reduces plasma levels of triglycerides, C-reactive protein, and malondialdehyde (MDA) in mice with fructose-induced hypertriglycemia in a dose-dependent manner.2It decreases glomerular and tubular atrophy and necrosis induced by cisplatin in rat kidney when administered at a dose of 100 mg/kg.3Fenofibrate also reduces the number of pulmonary lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in lung of Tsumura Suzuki obese diabetic (TSOD) mice.4 1.Willson, T.M., Brown, P.J., Sternbach, D.D., et al.The PPARs: From orphan receptors to drug discoveryJ. Med. Chem.43(4)527-550(2000) 2.Sun, B., Xie, Y., Jiang, J., et al.Pleiotropic effects of fenofibrate therapy on rats with hypertriglycemiaLipids Health Dis.14:27(2015) 3.Helmy, M.M., Helmy, M.W., and El-Mas, M.M.Additive renoprotection by pioglitazone and fenofibrate against inflammatory, oxidative and apoptotic manifestations of cisplatin nephrotoxicity: Modulation by PPARsPLoS One10(11)e0142303(2015) 4.Kuno, T., Hata, K., Takamatsu, M., et al.The peroxisome proliferator-activated receptor (PPAR) α agonist fenofibrate suppresses chemically induced lung alveolar proliferative lesions in male obese hyperlipidemic miceInt. J. Mol. Sci.15(5)9160-9172(2014) |