您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > 2-Fluoroadenine
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
2-Fluoroadenine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2-Fluoroadenine图片
CAS NO:700-49-2
包装与价格：
包装价格(元)
250mg电议
500mg电议
1 g电议

产品介绍
2-氟腺嘌呤是一种有毒的嘌呤碱基。 2-氟腺嘌呤对非增殖性和增殖性肿瘤细胞具有毒性。 2-氟腺嘌呤可用于抗癌研究。
Cas No.700-49-2
别名2-氟-6-氨基嘌呤
Canonical SMILESNC1=C2C(N=CN2)=NC(F)=N1
分子式C5H4FN5
分子量153.1
溶解度DMSO: slightly soluble,Ethanol: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2-Fluoroadenine is a heterocyclic building block that has been used in the synthesis of heat shock protein 90 (Hsp90) inhibitors that have anticancer activityin vitro.1It is also cytotoxic to CEM human leukemia cells with an IC50value of 0.15 µM.2

1.Llauger, L., He, H., Kim, J., et al.Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90J. Med. Chem.48(8)2892-2905(2005) 2.Parker, W.B., Allan, P.W., Shaddix, S.C., et al.Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cellsBiochem. Pharmacol.55(10)1673-1681(1998)